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Dry mouth appears as an uncommon trial adverse event and is typically mild and transient

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For example, GLP-1R-expressing vagal afferents have been shown to form intraganglionic laminar endings (IGLEs) mainly in the wall of the stomach/upper duodenum in mice [31, 32], such that they are selectively activated by gastric/duodenal stretch and CCK, but unexpectedly, not by exendin-4 [32]

However, these side effects are usually transient, and most people can tolerate them well

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