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Oral dosing relies on the peptide surviving stomach acid and GI enzymes, which reduces bioavailable fraction
In the dextran sulfate sodium (DSS) colitis model, the liraglutide group had significantly lower cecal occludin mRNA levels and significantly higher TNF- mRNA levels compared with the control group, with no difference in body weight (Fig
However, it is not clear whether the two forms are physiologically similar, especially when melanogenesis is concerned.
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It is less effective in the treatment of generalized waviness
Med 2 , a009399 (2012)
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