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ACTH, TSH, and glucagon may not activate adenylyl cyclase in vivo since the concentration of each hormone required in vitro is much higher than is found in the circulation
These pathways complement each other, creating a stronger overall effect
doi: 10.1038/onc.2013.191 165 MartinsLGalloCCHondaTSBAlvesPTStilhanoRSRosaDSet al
"Repurposed drugs as adjunctive treatments for mania and bipolar depression: A meta-review and critical appraisal of meta-analyses of randomized placebo-controlled trials"
This is distinct from hypertrophy, which is the growth of existing cells
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