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First, activating TGR5 by INT-777 down-regulated the phosphorylation levels of NF-B, which were further increased by PMA in HG and FFA co-stimulated HepG2 cells (Fig

has served on the Scientific Advisory Board of Adicet Bio and discloses consultant/honoraria from Ionis, Genentech, Nerviano, Secura Bio and Oncopeptides, and research funding from EMD Serono, Karyopharm, Sanofi, Nurix, BMS, H3 Biomedicine/Eisai, Springworks, Abcuro, Novartis and OPNA

2f is rate-limiting and no enzymesubstrate complexes accumulate in contrast to enzymes with typical MichaelisMenten kinetics 2,39,52

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