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Meaningful weight loss typically begins around weeks four through eight as the dose increases to therapeutic levels

Eur J Pharmacol 954:175896

They represent a fundamental shift in what medicine can offer to a population that has been failed by the assumption that behavior change alone should be sufficient

With a 6-day half-life, 4 half-lives = 24 days (roughly 3.5 weeks) and 5 half-lives = 30 days (roughly 4.5 weeks)

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