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This improvement is reflected in a reduction in the histopathological score of colonic tissues and a decreased colon weight-to-length ratio

The effects may also may vary by individual

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Shi, D., Mi, G., Shen, Y

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Modern pharmacologic approaches allow the relative contribution of each receptor to be quantitatively tuned, mitigating adverse effects while preserving efficacy ( 5.3 Central neuropeptides and the behavioral dimension of feeding Beyond gut-derived peptides, centrally expressed neuropeptides exert a profound influence over feeding behavior while simultaneously modulating stress, arousal, and reward pathways