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the cholinergic hypothesis (18) reflects deficits in intercellular communication

Neurol Clin 14(2):317335

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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

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Molecular Pharmaceutics, 14 (9), 2861-2863