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many times the total amount a patient would receive weekly from this injection

Anaphylactic reactions to thiamine are exceedingly uncommon (estimated incidence well below 1 %), but they have been documented

[4] However, consistently taking large amounts of vitamins from multiple sources could potentially increase the risk of side effects (for example, very high vitamin B intake from multiple supplements over time can cause neuropathy, and high niacin from many sources could affect your liver)

Because this formula contains niacinamide, a few people might experience a flushing reaction (warmth, redness of the skin) or slight itching, although niacinamide usually does not cause the intense skin flush that niacin (nicotinic acid) does

[2] The FDA approves manufactured drugs that undergo extensive clinical trials