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The activation occurs via trans -phosphorylation of two catalytic tyrosines (Y1234 and Y1235) located in the kinase domain, followed by the subsequent auto-phosphorylation of the two docking tyrosines (Y1349 and Y1356) in the C-terminal tail
The delivery of peptides is delicate
Standard GLOW protocol uses 0.9 to 1.8mg of the blend daily for 6 weeks
Huang, Y., He, Y., Makarcyzk, M
Important caveat: there are no completed controlled human clinical trials of injectable or systemic GHK-Cu
However, miR-101, miR-206, and miR-26a target c-Met/HGF and inhibit tumor growth and metastasis [182,183,184]
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