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The compound was active at very low doses and showed oral bioavailability, crossing the blood-brain barrier after systemic administration

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, 22 , 4104-4110, doi: Strohkamp, S., Gemoll, T., Humborg, S., Hartwig, S., Lehr, S., Freitag-Wolf, S., Becker, S., Franzn, B., Pries, R., Wollenberg, B., Roblick, U

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In addition to its synthesis, the activity of GR provides a secondary source of reduced glutathione (GSH) in the cytosol and certain organelles, such as the mitochondria [1, 2]