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doi: 10.1021/acschemneuro.3c00406 75 ZhangJ.ZhangT.ChenY.XuanX.ZhaoY.LuG
While the absorption rate is slightly lower than IV infusion, the results are still highly effective, especially when administered as part of a consistent treatment routine
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Folinic acid (2 mg/kg/day, max 50 mg/day) produced significantly greater improvements in standardized verbal communication scores and several adaptive and behavioral subscales compared with placebo, with a stronger effect on children ( Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism
In reality, these mechanisms are rooted in a misunderstanding of human physiology
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