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A 2025 narrative review of musculoskeletal research described both the regenerative findings and the open questions about translation to human clinical use (PMID 40789979)
Other groups have reported increased efficacy with 5FU and metformin in models of acquired resistance 53,54,55,56 , in spheroid culture 53 or xenograft/PDX models 57,58,59 , but the potential of combined 5FUCI inhibitor co-treatment in a chemo-naive, immune-competent setting requires further investigation
Exp Cell Res 228:5864 Broberg K, Bjork J, Paulsson K, Hoglund M, Albin M (2005) Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer
Muscle Loss Prevention: As we age, we may experience muscle loss and decreased muscle function, a process known as sarcopenia
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