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Moreover, GLP-1 exerts stabilizing effects on the endothelial contraction and barrier for AGE-treated endothelium via activating GLP-1R/cyclic adenosine monophosphate (cAMP)/PKA and inhibiting mitogen-activated protein kinase (MAPK) signaling pathways together with RAGE/Rho/ROCK [97, 98]
L-citrulline has been less extensively studied but preliminary evidence suggests it may be more effective than L-arginine due to better bioavailability
Acetic acid water (0.6%) is available as an alternate diluent for peptides that require mildly acidic conditions
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