To truly understand how glutathione operates, one must look at the continuous biochemical loop known as the redox (reduction-oxidation) cycle
GSH prevents protein oxidation through S-glutathionylation mechanisms
Oxoproline catalytically activates the uptake of amino acids through the placental barrier, and the transfer of amino acids through the bloodbrain barrier is activated by oxoproline ( FIGURE 5 Glutathione and damaging inflammation in lower respiratory diseases Glutathione Samsonian (mighty) power is centered in the thiol (sulfhydryl) group of the cysteine amino acid
Res Vet Sci 108:817 Aoki Y, Magata F, Miyamoto A, Kawashima C, Hojo T, Okuda K, Shirasuna K, Shimizu (2014) The effect of single nucleotide polymorphisms in the tumor necrosis factor- gene on reproductive performance and immune function in dairy cattle
[13] Tyrosinase is directly inhibited through chelation of the copper site by the thiol group
While this might be largely coincidental, current concepts suggest that the co-operative roles of ascorbate and glutathione in the FoyerHalliwellAsada pathway are among the most important pillars of the antioxidant network