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MounjaroTM (tirzepatide) injection, for subcutaneous use: US prescribing information (2022)

Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), people following vegan or strict vegetarian diets (as B12 is naturally found almost exclusively in animal products), individuals with pernicious anaemia or other malabsorption conditions, those taking certain medications such as metformin or proton pump inhibitors long-term, and people with significant nitrous oxide exposure (including recreational use), which can inactivate B12 in the body

This separation of therapeutic effect from GI side effect is one reason why many patients achieve their best weight loss results in months 36 of therapy

McCall McPhereson: So I'll tell you, this is definitely a fringe thing

I have been taking it for over 2 years for anti-aging