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Regarding contraception, for most GLP-1 medications (semaglutide, liraglutide), there is no clinically significant effect on oral contraceptive effectiveness
This makes it especially valuable for patients recovering from surgery or extensive injuries who want to regain full range of motion
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MT-II specifically: libido enhancement (MC4R-mediated), appetite reduction, and potential erectile effects
Noteworthy, the association of GLP-1RAs and SGLT-2is is representing a new pharmacological opportunity opening an innovative scenario with potential additive pleiotropic effects that will require further studies
December 13, 2022
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