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The GHRH signal (sermorelin) tells the pituitary to release GH, while the ghrelin signal (ipamorelin) both adds a second release stimulus and lifts somatostatin's inhibitory brake

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This leads to better control of blood sugar levels

Both trials suggest maintenance strategies, such as lower-dose injections or oral therapies, could offer patients more flexible, potentially more convenient options for sustaining weight loss after intensive treatment

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Ghrelins potential to increase reward responses was discovered in rodent studies investigating motivated behaviour as well as dopaminergic transmission