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Epitalon Human and Animal Evidence The evidence base for Epitalon is dominated by Russian-language publications from Khavinson's group, many of which were conducted between 1990 and 2010

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Additionally, pharmaceutical medications, while therapeutically necessary, often generate oxidative stress as a side effect of their metabolism

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In studies of GPX5 knockout mice, we deduced that GPX5 is a way to maintain the integrity of sperm DNA function by removing excess H 2 O 2 , and these mice did not exhibit significant defects in the epididymis and sperm cells ( 2 O 2 scavengers was detected (Noblanc et al., 2012), proving that after SNGPX4 and GPX5 double knockouts, the epididymal tissues of mice produced oxidative stress responses, indicating that SNGPX4 and GPX5 play a role in maintaining the normal structure of the sperm nucleus in the epididymal tissue (Noblanc et al., 2012)