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Retatrutide has produced weight loss results that far exceed those of semaglutide (Ozempic), reducing weight by up to 24% in 48 weeks, compared to semaglutides 17.4% reduction after 68 weeks
Contraindications: Patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use this drug
Better glycemic control reduces oxidative stress and vascular inflammation, potentially improving blood flow to sexual organs and enhancing physiological arousal capacity
Models and AML cells assigned to subtypes C1 and C8 were more sensitive to mTOR inhibition than others
Several animals studies have found that GLP-1 agonists can reduce drug and alcohol seeking behavior, but there isnt strong data from human trials: one small trial found that GLP-1 agonists could reduce opioid cravings, for example, while another found they could reduce cravings for alcohol, but only in people who were living with obesity
Additionally, its worth repeating that semaglutide is not approved for or effective in managing type 1 diabetes
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