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Elevated cortisol levels increase gluconeogenesis in the liver, impair insulins ability to translocate GLUT4 to the cell surface, and raise portal and peripheral free fatty acids [72, 73]
Furthermore, in participants with T2D, treatment with the selective long-acting GIP receptor agonist, macupatide, was associated with a larger insulin sensitivity improvement compared with the selective GLP-1 receptor agonist dulaglutide, despite similar body weight reduction, and combination therapy with these agents was associated with additive effects on insulin sensitivity [20]
Insurance coverage is generally more supportive of FDA-approved uses, which guides many toward Zepbound for weight management
however, if additional blood tests such as glucose or lipid panels are requested, fasting for 812 hours may be necessary for accurate results
