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Additionally, a 7-year prospective study found that while NSW alone was not significantly associated with chronic pain or CRP levels, the combination of NSW and moderately elevated CRP was associated with an increased risk of chronic pain and pro-inflammatory background 150

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Additionally, by blocking the NF-B signaling pathway, paroxetine therapy inhibits the pyroptosis-related pathway triggered by IL-1 and reduces the extracellular matrix disintegration

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