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As a novel GLS1 inhibitor, the recent reported compound 19 (C19) is thought to have a similar or greater ability to inhibit anti-CD3/CD28-induced CD4 + T cell proliferation and cytokine production by directly binding to the GAC outside the active site compared to BPTES (55)

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Vitamin B12, also known as cobalamin, plays a crucial role in: Red blood cell production Nerve function DNA synthesis Energy production and metabolism A deficiency in Vitamin B12 can lead to fatigue, anemia, nerve damage, and cognitive issues

We included data from 2017 to 2020 because it was during this period that the survey on gallstones was conducted