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According to experimental evidence, the crotonylation status of lysine residues 354 and 553 on the MTHFD protein is modulated by the enzymatic complexes p300/CBP, HDAC1, and HDAC3.Low crotonylation promotes NADPH production, inhibits ferroptosis, and drives PDAC progression

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The only two authoritative sources that have a strong stance on this are as follows Dr