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While thorough questionnaires can identify most contraindications and risk factors, the lack of physical examination may miss subtle signs of underlying conditions that could affect treatment safety or efficacy

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All strengths will be available from the manufacturer as the shortage has ended, but after April 22, 2025, compounding pharmacies will be only able to make custom doses

Neurofilament light chain sits slightly apart, useful both as a marker of ongoing neuroaxonal damage and as a safety signal when it moves the wrong way, as it arguably did in EVOKE