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In pre-specified analyses at 52 weeks, participants who switched to orforglipron from Wegovy maintained their previously achieved weight loss with an average difference of 0.9 kg, while those who switched to orforglipron from Zepbound maintained their previously achieved weight loss with an average difference of 5.0 kg, using the efficacy estimand

Contact your provider or seek emergency care if you experience: Seizures Severe mood changes (including worsening depression or suicidal thoughts) Hallucinations, paranoia, or confusion Rapid or irregular heartbeat Signs of an allergic reaction (such as a rash, swelling, or difficulty breathing) On top of the above, Wellbutrin carries an FDA black box warning about the potential for increased suicidal thoughts and behaviors in children, adolescents, and young adults

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[Accessed 26/01/2026] Loperamide (Imodium)

but plans to continue expanding the outreach around the world

Some patients may lose 510% of body weight, especially with the higher dose of liraglutide