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They work by mimicking the action of the naturally occurring hormone GLP-1, which is involved in regulating blood sugar and appetite
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Both compounds gastrointestinal effects are dose-related, which is exactly why both trial programmes escalate slowly by design
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In in vitro studies GLP-1 receptor agonism is associated with regulation of several inflammatory pathways, including cytokine production, lypotoxicity and macrophages differentiation
Adoption is expected to improve as oral formulations reduce injection concerns among patients starting long-term therapy
