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Aroda, MD, who specializes in endocrinology, diabetes, and hypertension at Brigham and Womens Hospital in Boston

Glucagon receptor activation, for example, raises theoretical concerns about hepatic glucose output though clinical data from retatrutide trials show that the GLP-1 component effectively counterbalances this effect in the context of the triple agonist

While short-term anti-inflammatory effects can be helpful, long-term immune regulation --- especially in patients with autoimmune conditions --- needs careful monitoring

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In addition, AT remains the most commonly studied source of immune-mediated inflammation in obesity