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Published research has demonstrated that disrupted circadian signaling in aging is associated with increased cancer risk (DNA repair timing is compromised), metabolic dysfunction (insulin sensitivity follows a circadian pattern), impaired immune surveillance (immune cell activity peaks at specific circadian phases), and accelerated cardiovascular aging (blood pressure regulation is circadian-dependent)
This contributes to a sustained weight loss for adults meeting specific body mass index (BMI) criteria indicative of obesity or being overweight
1,12 [corrected] Clinical evaluation seems to show an inverse relationship between the severity of megaloblastic anemia and the degree of neurologic impairment
