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Mechanistic and translational studies suggest that metabolic dysregulation that occurs with obesity, particularly hyperglycemia and insulin resistance, contributes to altered immune cell function and low-grade systemic inflammation

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Diaz-Vivancos, P., de Simone, A., Kiddle, G

Dietary modifications represent the first-line approach to managing nausea and other digestive symptoms: Eat smaller, more frequent meals rather than large portions, which can overwhelm the already-slowed digestive system Avoid high-fat, greasy, or spicy foods , as these are more difficult to digest and may exacerbate nausea Stay well hydrated , sipping water throughout the day rather than drinking large amounts at once Eat slowly and chew thoroughly to aid digestion and reduce bloating Avoid lying down immediately after eating

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For lyophilized semaglutide, maintaining low humidity levels during storage is crucial