The BBB helps maintain the homeostasis of the brain
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Diabetes Care, 49 (Supplement_1), S321S338
Metformin also alters the intestinal microbiome (Vallianou 2019), increases intestinal glucose utilization, and stimulates GLP-1 secretion
Real-world patients often maintain some of the behavioral changes they developed during treatment
Many people continued other forms of treatment after stopping GLP-1 drugs, which may help explain why large weight regain was not commonly observed