Pay in 4 interest-free payments of $5.17 Learn more
Ships within 48 hours · Estimated delivery Aug 23 - Aug 28
Currently, several therapies are emerging and undergoing trials in animal models
Blood tests may be conducted to measure your Vitamin B12 levels
Kirkland, Identification of a novel senolytic agent, navitoclax, targeting the Bcl2 family of antiapoptotic factors
Ovarian cancer is the sixth most common malignancy among women in developed countries and the fifth leading cause of cancer-related death, representing a complex disease associated with poor survival rates.24 The combination chemotherapy of Paclitaxel (PTX) and Carboplatin (CARB) is considered the first-line treatment regimen for ovarian cancer.25 Both agents play distinct roles in inhibiting the growth of ovarian cancer through different mechanisms,26 and they are known to exert a synergistic anti-tumor effect by activating separate apoptotic signaling pathways, thereby potentially reducing drug resistance.25 The gonadotoxic effects of platinum-based chemotherapeutic agents have been demonstrated in numerous studies, both histopathologically and in terms of follicular development.27-29 In the present study, CARB administration led to significant histopathological damage in ovarian tissue, including follicular degeneration, prominent stromal edema, congestion, hemorrhage, inflammation, and fibrosis, particularly in the medullary region
Anti-inflammatory cytokines regulate mature neurogenesis in response to immune activation, while the neurovascular system controls the neural stem cell niche (Vallon and Chang 2014)
Researchers should consult safety literature and institutional guidelines when using this compound in their experimental design
