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At therapeutically and research-relevant doses, MC4R is the primary pharmacologically active receptor both because it has the highest CNS expression density in regions governing sexual behaviour and because MC1R-mediated pigmentation effects (the basis of the tanning response to MT-II) are substantially attenuated in PT-141s cyclic structure
Gombos and C
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Response rate analysis also showed a significant main effect of alcohol dose (F(3, 42) = 3.68, p = 0.019), though post-hoc comparisons did not reveal significant differences among individual doses (Fig
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