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The enzyme dipeptidyl peptidase 4 (DPP-IV) cleaves it between the second and third residues which renders it inactive within several minutes, and explains why GLP-1 cannot be used as a drug itself

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GLP-1's Half-Life and Dosing Timeline Long-acting GLP-1 receptor agonists such as semaglutide have an elimination half-life of about 7 days, which allows for once-weekly dosing

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