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Two estimands were employed: the trial product estimand, which evaluated treatment effects assuming perfect adherence to the assigned regimen, and the treatment policy estimand, which included all randomized participants regardless of adherence

As IAP antagonists induce the degradation of IAP proteins such as cIAP1/2 and can inhibit the activity of XIAP [50], we hypothesised that combination treatment of b-AP15 and IAP antagonists may be synergistic in HNSCC cells

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LaRocca TJ, Sosunov SA, Shakerley NL, Ten VS, Ratner AJ

Animal studies have indicated that GHRH agonists may reduce myocardial infarct scarring in swine [8]