If you arent deficient, you may experience side effects taking a supplement
But what does this mean for those in the lab
Oral glucose tolerance testing revealed that AOD-9604 has no negative impact on carbohydrate metabolism
It's generally appropriate for adults with a BMI of 30 or higher, or 27 or higher alongside a condition like high blood pressure, high cholesterol, or type 2 diabetes
Reported applications include NNMT enzyme inhibition assays measuring 1-methylnicotinamide formation or S-adenosylhomocysteine release, intracellular target-engagement assays in differentiated 3T3-L1 adipocytes where 5-Amino-1MQ reduced intracellular 1-methylnicotinamide with an EC near 2.3 M (Neelakantan et al., Biochem Pharmacol, 2018), membrane permeability and Caco-2 transport characterisation, methyltransferase selectivity panels covering COMT, DNMT1 and PRMT3, and rodent studies of NNMT inhibition in adipose tissue and liver following the antisense knockdown work of Kraus and colleagues (Nature, 2014)
For the starting dose phase (2 mg per week), 5 mg/mL or 10 mg/mL both work well