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47,48 Moreover, active or inactive drug metabolites can influence both efficacy and adverse effects, as seen with prodrugs such as cyclophosphamide
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101 Enhanced DNA damage repair mechanisms contribute similarly: in BRCA2-deficient tumors, reduced EZH2 expression stabilizes replication forks, diminishing sensitivity to PARP inhibitors (PARPis)
The samples were centrifuged at 21,000 g for 3 min to pellet any insoluble materials
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