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Dysregulated iron homeostasis amplifies ferroptotic susceptibility through Fenton chemistry-driven lipid peroxidation and polyamine synthesis via the ODC1-MYC axis, a metabolic and oxidative cascade prominently observed in the inflamed synovium of rheumatoid arthritis ( Inducing ferroptosis in specific cell populations using agents like Imidazole ketone erastin (IKE) can suppress synovial fibroblast proliferation and inflammation (104)

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Alm da melhora no desempenho da atividade fsica, o aumento da fora muscular tambm observado em indivduos portadores de DAP depois de quatro semanas de suplementao (2g/dia) com propionil-L-carnitina 15

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