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"Patients on GLP-1 agonists are prone to losing muscle mass if they do not consume enough protein, especially if they are sedentary." The good news: Meat is far from your only protein option, and you likely won't feel repulsed by a juicy steak forever
It is a known side effect that is actually pretty common
There may be direct pharmacological effects through central GLP-1 pathways, as well as indirect consequences of the medication's intended actions and associated side effects
Randomized controlled trials before the issue of CVOTs by the FDA in 2008 mainly focused on the efficacy of the blood glucose-lowering effects and a broad spectrum of adverse effects, with limited numbers of cardiovascular adverse events and relatively short follow-up duration
As weve discussed here before, we have a weight loss program in our practice that offers patients semaglutide (the active ingredient in Ozempic and Wegovy) and tirzepatide (the active ingredient in Mounjaro)
Patient characteristics and incidence of cardiac amyloidosis: an observational study in the UK clinical setting using electronic health records
