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At the intranasal doses used in Schneider-Helmert's human protocols (roughly 25 to 30 nmol/kg), the resulting total dose for an average adult falls in the low-to-mid microgram range, substantially less than the milligram-level doses commonly sold in single vials

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Preclinical work on GHK-Cu supports a role in collagen synthesis and tissue repair, though human trial data is limited

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Premature overload risks reinjury while excessive restriction produces suboptimal tissue quality