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GLP-1 receptor agonists were originally developed to improve glycemic control

Primary indication is diabetes management based on blood glucose criteria, not BMI

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Limited observational data and case reports suggest that GLP-1 receptor agonists do not adversely affect thyroid function in patients with pre-existing hypothyroidism who are maintained on stable levothyroxine therapy

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Thus, multiple biological mechanisms may be involved in the sex difference in pSer-IRS-1 in L1CAM exosomes isolated from subjects with MDD