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Comparative efficacy and safety of glucagon-like peptide-1 receptor agonists in children and adolescents with obesity or overweight: A systematic review and network meta-analysis
They should also discuss alternative strategies for managing side effects within the FDA-approved framework, such as temporarily maintaining a lower dose level for an extended period if gastrointestinal symptoms are problematic, or using supportive medications to control nausea
Common underlying mechanisms include nerve damage (peripheral neuropathy), inflammatory processes affecting nerve tissue, or changes in neurotransmitter function within pain pathways
Patients with pre-existing liver disease or those taking medications metabolized through one-carbon pathways should consult their prescribing physician before starting lipotropic therapy
They mimic the actions of the endogenous incretin hormone GLP-1 that is released by the gut after eating
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