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h , i , Energy expenditure in fasted mice with chemogenetic AP GLP1R ( h ) or NTS GLP1R ( i ) neuron activation (n = 11 mice/group)
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Cells were treated for 5, 8 and 24 h with the synthesized PROTACs at concentrations between 1 M and 5 M ( Supplementary Figure 2B ), but no significant reduction of RNF4 was observed under any of these conditions
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