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The Elephant in the Room: It's Still About Cost By far the most significant factor in a patient's decision

Heres why use of SGLT2 inhibitors causes an increased risk of this adverse event: The stress of surgery, change in dietary intake, and possible reduction in insulin dose around the time of surgery already disrupts blood sugar regulation

These medications are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Patients should also seek evaluation if they experience numbness, tingling, or color changes in fingers and toes (particularly white, blue, or red discoloration), which could indicate peripheral vascular issues or Raynaud's phenomenon rather than simple cold sensitivity

Patients often notice a reduction in appetite shortly after starting the medication, leading to gradual and steady weight loss

Lifestyle changes Quitting smoking, avoiding pollution, and eating a healthy diet can slow disease progression