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Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential

Vitamin B12 deficiency is one of the most common nutrient deficiencies in the world, especially for vegetarians, vegans and people with health conditions such as Crohns Disease or Celiac Disease which makes it hard to absorb nutrients

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These factors suggest starting slightly higher than the minimum effective clinical dose to account for real-world variability

Avoid aggressive shaking, as excessive agitation may affect product stability

Allergies and medical conditions Those with allergies or medical conditions should always inform a doctor before receiving a vitamin B12 shot