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In people with obesity without diabetes (SURMOUNT-1 trial), higher doses achieved weight loss of up to 20% over 72 weeks, while in type 2 diabetes (SURPASS trials), the weight loss was typically lower

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

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These observations warrant careful interpretation

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When to call your doctor Call your healthcare provider if you experience: Severe or prolonged nausea or vomiting, especially if you have a hard time keeping down fluids Persistent abdominal pain Dizziness Dark urine Weakness Many people find that nausea from Ozempic improves over time