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The mean duration of type 2 diabetes mellitus was 8.6 years, and the mean BMI was 34 kg/m 2

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The most explored mechanisms are inflammation, the induction of apoptosis, destruction of the blood-testis barrier, and oxidative stress (34, 35)

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Cagrilintide a long-acting amylin analog (half-life ~165 hours) that enhances satiety, slows gastric emptying, and suppresses postprandial glucagon via brainstem amylin receptor activation