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Studies have shown that lactate can inhibit the polarization of M1 proinflammatory macrophages while promoting the polarization of M2 macrophages toward an anti-inflammatory and proangiogenic phenotype, with these effects being mediated through various mechanisms, including histone posttranslational modifications and signaling pathway regulation (107, 108)

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Lancet Infect Dis 20:e276e288 Ricke DO (2021) Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies

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