Byetta and Bydureon (exenatide) : among the earliest GLP-1 medications approved in the United States, available in twice-daily and once-weekly injectable forms
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Lastly, a high-fat diet supplemented with 10% guar gum over a duration of 12 weeks is introduced to C57B mice, resulting in the production of short-chain fatty acids through colonic fermentation that stimulate GLP-1 release, thereby enhancing glucose clearance [28]
Across the SLD spectrum, GLP-1 RAs demonstrated modest but directionally consistent improvements in liver enzyme profiles (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]), with 4 of the 7 ALT outcome estimates showing significant reductions, and 4 of the 9 AST outcome estimates showing significant reductions
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