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Reconstruction of missing residues in the trimeric spike As initial model for our analysis we used a pre-fusion structure of the trimeric S-protein solved by cryo-EM at 2.80 resolution 14 (PDB id 6VXX)

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308 AMPK signaling pathway Metformin is a well-known activator of AMPK that functions by reducing the ADP/ATP and AMP/ATP ratios (Table 1)