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Examples encompass fluorocarbon chain-functionalized hollow mesoporous organosilica nanoparticles (FHMONs), hemoglobin-based nanoprobes, pH-sensitive nanocarriers, and redox-responsive nanocarriers, which can mitigate hypoxia, augment photodynamic therapy, release drugs in the acidic milieu of tumors, and transport antioxidants or therapeutic agents

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Even though variable GSH concentrations were not tested, the authors suggested that Lys19 replacements have a negative effect on the reactivity of the glutathionylated enzyme with the reducing agent